Common Errors That Occur During Bile Acid Metabolism
It takes the liver at least 14 enzymatic steps to generate bile acids from cholesterol, and the process takes place in a complicated chain of events. The inability to carry out any of these processes will lead to a failure to create "normal bile acids" and the buildup of odd and intermediate bile acid metabolites due to the failure to carry out any of the reactions above. Bile acid production is impaired, which results in reduced bile flow and impaired intraluminal solubilization of fat and fat-soluble vitamins. When the bile acid biosynthesis pathway is blocked, the produced intermediates may be harmful to the hepatocytes in certain instances. Infants, toddlers, and adults have been discovered with several documented inborn defects in bile acid metabolism that cause enzyme shortages as well as decreased bile acid production. Symptoms of fat and fat-soluble vitamin malabsorption may be evident in patients who have had neonatal cholestasis or neurologic illness. Lower intest...
Comments
Post a Comment