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What Are Bile Acid Metabolites & How The Health Issue Is Treated?

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As the gut microbiota contributes to metabolic health, it is important to determine specific diet-microbiota interactions that influence the host of metabolism. Bile acid metabolites can alter phenotypes of diet-induced obesity. The bacterial bile acid metabolites, termed secondary bile acids, are more hydrophobic than primary bile acids produced by the liver. As the gut microbiota contributes to metabolic health, it is important to determine specific diet-microbiota interactions that influence host metabolism.   Bile acids and dietary fat sources can alter phenotypes of diet-induced obesity, but the interplay with intestinal microorganisms is unclear.  Bile contains bile acids that are crucial for the digestion and absorption of fats and fat-soluble vitamins in the small intestine. Waste products like bilirubin are eliminated from the body by secretion into bile and elimination in feces. The Role of Bile Acid in Fat Digestion and Absorption Bile acids are the byproducts of c...
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Common Errors That Occur During Bile Acid Metabolism

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It takes the liver at least 14 enzymatic steps to generate bile acids from cholesterol, and the process takes place in a complicated chain of events. The inability to carry out any of these processes will lead to a failure to create "normal bile acids" and the buildup of odd and intermediate bile acid metabolites due to the failure to carry out any of the reactions above. Bile acid production is impaired, which results in reduced bile flow and impaired intraluminal solubilization of fat and fat-soluble vitamins. When the bile acid biosynthesis pathway is blocked, the produced intermediates may be harmful to the hepatocytes in certain instances. Infants, toddlers, and adults have been discovered with several documented inborn defects in bile acid metabolism that cause enzyme shortages as well as decreased bile acid production. Symptoms of fat and fat-soluble vitamin malabsorption may be evident in patients who have had neonatal cholestasis or neurologic illness. Lower intest...
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